Nutrition and Cancer 2001, Vol. 40, No. 2, Pages 149-156
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| Green Tea and Its Catechins Inhibit Breast Cancer Xenografts | |
| Tạp chí Nutrition and Cancer 2001 March 3; 40 (2):149-156 | |
| Tác giả | Maryam R. Sartippour, David Heber, Jiyuan Ma, Qingyi Lu, Vay Liang Go, Mai Nguyen |
| Nơi thực hiện | Department of Surgery, University of California, Los Angeles, CA 90095, USA |
| Từ khóa | EGCG,GTE,Green Tea,Breast Cancer |
| DOI URL [ PDF] | |
English[sửa]
Investigators have shown that green tea may decrease the risk of cancer. It is widely accepted that the main active component of green tea is epigallocatechin-3-gallate (EGCG). In this study, we examined the effect of green tea on breast cancer growth and endothelial cells in in vitro assays and in animal models. Furthermore, we compared the potency of the different catechin components of green tea extract (GTE), including EGCG. Our data showed that mixed GTE and its individual catechin components were effective in inhibiting breast cancer and endothelial cell proliferation. In mouse experiments, GTE suppressed xenograft size and decreased the tumor vessel density. Our results demonstrated the value of all catechins and argued for the use of a mixed GTE as a botanical dietary supplement, rather than purified EGCG, in future clinical trials
