European Journal of Organic Chemistry, Vol 2005, Issue 18 , Pages 3952 - 3961

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The Design and Synthesis of New Steroidal Compounds as Potential Mimics of Taxoids
 Tạp chí European Journal of Organic Chemistry 2005 4 Aug; 2005 (18):3952 - 3961
 Tác giả   Fanny Roussi *, Quoc Anh Ngo, Sylviane Thoret, Françoise Guéritte, Daniel Guénard
 Nơi thực hiện   Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France, Fax: +33-1-69077247
 Từ khóa   Antitumor agents ,Asymmetric synthesis ,Medicinal chemistry ,Steroids
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English

Abstract

Eight new steroidal compounds bearing the phenylisoserine and benzoate side-chains of docetaxel were synthesised as potential mimics of antitumour taxoids. They were readily obtained either from cholic acid or from 4-androstene-3,17-dione by a reductive Tsuji-Trost/reduction one-pot reaction. Two compounds showed an unexpected inhibitory activity of tubulin assembly. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

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