Proceeding of the Second International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevant, p. 185.

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 Tạp chí Proceeding of the Second International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevant 1996 ; ():185
 Tác giả   Vo Van Toi and P.A. Grounauer*
 Nơi thực hiện   Department of Biomedical Engineering, Bioengineering Center,Tufts University, 4 Colby Street, Medford, MA 02155

*Hôpital Ophtalmique Universitaire de Lausanne, Switzerland

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Purpose: Dry eye patients need constant and permanent application of artificial tears. To effectively administer medication and improve patient's compliance we developed a device which automatically delivers a single drop of medication at a programmable rate to the patient’s eyes.

Description: The instrument consists of a case (120x70x40 mm) connected to a pair of ejector nozzles via a flexible tubing (3 mm diameter). The case fits in a shirt pocket and nozzles can be mounted on an eyeglass frame. T he device is powered by a 9 volt battery; its electronic control contains an 8 bit microcontroller monitoring the ejection mechanism at different speeds and frequencies. This unique design permits the user to preset the droplet volume (from 1 to 20 m l) and ejection pace (from one drop/second to one drop/four hours). The automatic control can be overridden temporarily by pressing a button to obtain additional drops at will. Since only one droplet is administered to the eye inste ad of a spraying mist, the medication completely enters the eye. The medication is kept separate from the drive mechanism in a fluid cartridge, designed for one-day use, disposable, and replaceable by the user. Therefore the medication sterility can be pr eserved and risk of contamination or altering medication characteristics can be avoided. The microdrops are formed by the action of a patented ejection mechanism. It functions by producing a positive pressure to form the droplet, followed by a negative pr essure to sever the droplet from the nozzles. This permits the generation of adequately small drops, ejected with an appropriate momentum. Additionally, the negative pressure pulls the remaining solution into the tube, keeping the nozzles clean, and preve nting liquid from drying and subsequent clogging. The action of advancing and reversing is the key to the invention, which differentiates it from peristaltic pumps and other atomizing devices. The design is highly efficient and the battery lasts for many months. It can be used for patients of all ages.

Conclusion: This device can be of great benefit to the intended population and to researchers who need an adequate tool for physiological, medical, and pharmaceutical studies to investigate medication effects or to develop new medications.

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