Progress in Biomedical Optics and Imaging, vol. 6, No. 8 ISSN 1605-7422, p. 495-502
|Hemodynamic variations measured with near-infrared spectroscopy in human forearm muscles in response to venous occlusion: An electrical model|
|Tạp chí Progress in Biomedical Optics and Imaging 2005 ; 6 (8):495-502|
|Tác giả||Vo Van Toi *, Matthew L. Hoimes, Shalini Nadgir, and Sergio Fantini|
|Nơi thực hiện||Department of Biomedical Engineering, Bioengineering Center,Tufts University, 4 Colby Street, Medford, MA 02155|
|Từ khóa||near-infrared spectroscopy,hemoglobin concentration,oxygen saturation,venous occlusion, circulatory system, vascular compliance, electrical modeling|
|DOI URL [ PDF]|
We present data collected with near-infrared spectroscopy on the human forearm (brachioradialis muscle) to characterize the hemodynamic response to venous occlusion in muscle. Venous occlusion was achieved in the upper arm by inflating a pneumatic cuff to a pressure of 60 mmHg. We performed absolute measurements of concentration and oxygen saturation of hemoglobin on six healthy adult human subjects. On all six subjects, we consistently found that during a 40-s venous occlusion the hemoglobin concentration increases (by 5.6±2.3 mM), while the oxygen saturation of hemoglobin decreases (by 2.1±0.7%). This accumulation and desaturation of blood in the forearm in response to the upper arm occlusion can be described with an electrical model in which the charge stored by a capacitor represents the local blood volume, and the electrical current represents blood flow.